Insights into Therapeutic Peptides and their Quality Control
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Abstract
Therapeutic peptides have been garnering renewed attention in recent years. The manufacturing of peptides and protein-based drugs rapidly expands within the pharmaceutical sector. These compounds may be obtained through solid-phase synthesis or biotechnological methods. Peptides and proteins are delicate molecules that undergo chemical or physical changes such as oxidation of methionine, deamidation of asparagine and glutamine, isomerization, aggregation, and denaturation during production. The alterations could compromise the stability of the drugs, consequently impacting the therapeutic efficacy of the protein or peptide. It is essential to effectively monitor the quality of proteins or peptides to verify the preservation of their biological properties throughout the production process. This review outlines the official guidelines for quality control of peptides manufactured through solid-phase synthesis or genetic engineering. The discussion also covered the frequently utilized separation techniques for evaluating the efficacy of therapeutic peptides.
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Wang L, Wang N, Zhang W. et al. Therapeutic peptides: current applications and future directions. Sig Transduct Target Ther 7, 48 (2022). https://doi.org/10.1038/s41392-022-00904-4
Isbera M, Abbood A, Ibrahim W. Weight and Content Uniformity of Warfarin Sodium Half Tablets. Research Journal of Pharmacy and Technology. 2016; 9(3):215-218. doi: https://doi.org/10.5958/0974-360X.2016.00039.1
Abbood A, Layka R. Weight and content uniformity Study of captopril half-tablets. Research Journal of Pharmacy and Technology. 2017;10(6):1621-1626. doi: https://doi.org/10.5958/0974-360X.2017.00285.2
Chbani D, Abbood A, Alkhayer M. Determination of Nitrite and Nitrate Ions levels in some types of processed meats marketed locally. Research Journal of Pharmacy and Technology. 2018;11(4):1442-1447. doi: https://doi.org/10.5958/0974-360X.2018.00269.X
Abbood A, Malek Z, Al-Homsh Y, Thallaj N. In vitro Study for Antibiotic resistance of bacteria causing Urinary Tract Infection from Syrian adults. Research Journal of Pharmacy and Technology. 2022;15(10):4727-2. doi: https://doi.org/10.52711/0974-360X.2022.00794
Rossino G, Marchese E, Galli G, Verde F, Finizio M, Serra M, Linciano P, Collina S. Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era. Molecules. 2023 Oct 19;28(20):7165. doi: https://doi.org/10.3390/molecules28207165
Abbood A, Malek Z, Thallaj N. Antibiotic resistance of urinary tract pathogens in Syrian children. Research Journal of Pharmacy and Technology. 2022;15(11):4935-9. doi: https://doi.org/10.52711/0974-360X.2022.00829
Abbood A. Determination of phenolic content and antioxidant activity of some cosmetic creams available in the Syrian market. Journal of Chemical and Pharmaceutical Sciences. 2018;11:280-3. DOI: https://doi.org/10.30558/jchps.20181104006
Zrekah GH, Diab DA, Abboud AY. Determination of Protein and fat oxidation levels in imported infant formula available in Syria. International Journal of Pharmacy and Pharmaceutical Sciences. 2016;8:169-72. https://journals.innovareacademics.in/index.php/ijpps/article/view/9899
Abbood A. Optimization of the Imaged cIEF Method for Monitoring the Charge Heterogeneity of Antibody-Maytansine Conjugate, Journal of Analytical Methods in Chemistry, 2023, Article ID 8150143, 10 pages. https://doi.org/10.1155/2023/8150143
Lau JL, Dunn MK. Therapeutic peptides: Historical perspectives, current development trends, and future directions. Bioorg Med Chem. 2018;26(10):2700-2707. doi: https://doi.org/10.1016/j.bmc.2017.06.052
Abbood A. Study of formulation effects on the charge variant profile of antibody-maytansine conjugates by icIEF method. Acta Pharm. Sci. 2024: 62 (2): 288-300. Doi: https://doi.org/10.23893/1307-2080.APS6219
Abbood A, Monitoring the charge variant profile of antibody-tomaymycin conjugates by icIEF method, Acta Pharm. Sci. 2024, 62 (1), 226-239. Doi: https://doi.org/10.23893/1307-2080.APS6215
Fetse J, Kandel S, Mamani UF, Cheng K. Recent advances in the development of therapeutic peptides. Trends Pharmacol Sci. 2023;44(7):425-441. doi: https://doi.org/10.1016/j.tips.2023.04.003
Abbood A, Herrenknecht C, Proczek G, Descroix S, Rodrigo J, Taverna M, Smadja C. Hexylacrylate-based mixed-mode monolith, a stationary phase for the nano-HPLC separation of structurally related enkephalins. Anal Bioanal Chem. 2011 Apr;400(2):459-68. doi: https://doi.org/10.1007/s00216-011-4762-4
Kumar V, Barwal A, Sharma N, Mir DS, Kumar P, Kumar V. Therapeutic proteins: developments, progress, challenges, and future perspectives. 3 Biotech. 2024;14(4):112. doi: https://doi.org/10.1007/s13205-024-03958-z
Asaad RA, Abdullah SS. Breast Cancer Subtypes (BCSs) Classification according to Hormone Receptor Status: Identification of Patients at High Risk in Jableh- Syria. Research J. Pharm. and Tech. 2018; 11(8): 3703-3710. doi: https://doi.org/10.5958/0974-360X.2018.00680.7
Asaad RA. Hormone Receptor Status and its Relation to C-Reactive Protein and other Prognostic factors in Breast Cancer in Jableh- Syria. Research J. Pharm. and Tech. 2017; 10(9): 3003-3010. doi: https://doi.org/10.5958/0974-360X.2017.00532.7
Morkus R, Abbood A. A Survey of the Awareness and Practices of Antibiotic Use Among College Undergraduates and Graduates in Latakia. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) ISSN: 2582-7618, Volume-4 Issue-3, April 2024. DOI: https://doi.org/10.54105/ijapsr.C4039.04030424
Drucker DJ. Advances in oral peptide therapeutics. Nat Rev Drug Discov 19, 277–289 (2020). https://doi.org/10.1038/s41573-019-0053-0
Lee AC, Harris JL, Khanna KK, Hong JH. A Comprehensive Review on Current Advances in Peptide Drug Development and Design. Int J Mol Sci. 2019 May 14;20(10):2383. doi: https://doi.org/10.3390/ijms20102383
Machkour A, Thallaj NK, Benhamou L, Lachkar M, Mandon D. he Coordination Chemistry of FeCl3 and FeCl2 to Bis [2‐(2, 3‐dihydroxyphenyl)‐6‐pyridylmethyl](2‐pyridylmethyl) amine: Access to a Diiron (iii) Compound with an Unusual Pentagonal‐Bipyramidal/Square‐Pyramidal EnvironmentChemistry–A European Journal. 2006 :25;12(25): 6660-6668. Doi: https://doi.org/10.1002/chem.200600276
Labban L, Thallaj N. The Effect of Magnesium Supplementation on Hba1c Level and Lipid Profile Among Type 2 Diabetics. Acta Scientific Nutritional Health, 2019, 3,10, 7-12. DOI: https://doi.org/10.31080/ASNH.2019.03.0435
Sabogal De La Pava ML, Tucker EL. Drug shortages in low- and middle-income countries: Colombia as a case study. J Pharm Policy Pract. 2022;15(1):42. Published 2022 Jun 13. doi: https://doi.org/10.1186/s40545-022-00439-7
Ravela R, Lyles A, Airaksinen M. National, and transnational drug shortages: a quantitative descriptive study of public registers in Europe and the USA. BMC Health Serv Res. 22022:2:940. Doi: https://doi.org/10.1186/s12913-022-08309-3
Labban L, Thallaj N, Malek Z. The implications of E-cigarettes or" vaping" on the nutritional status. Journal of Medical Research and Health Sciences. 2019, 2, 11, 784-787. Doi: https://doi.org/10.15520/jmrhs.v2i11.128
Labban L, Thallaj N, Labban A. Assessing the Level of Awareness and Knowledge of COVID-19 Pandemic among Syrians. Archives of Medicine, 2020, 12, 2:8, 1-5. DOI: https://doi.org/10.36648/1989-5216.12.2.309
Videau M, Lebel D, Bussières JF. Drug shortages in Canada: Data for 2016-2017 and perspectives on the problem. Ann Pharm Fr. 2019;77(3):205-211. doi: https://doi.org/10.1016/j.pharma.2018.11.007
Kim H, Taslakjian B, Kim S, Tirrell MV, Guler MO. Therapeutic Peptides, Proteins, and their Nanostructures for Drug Delivery and Precision Medicine. Chembiochem. 2024;25(8):e202300831. doi: https://doi.org/10.1002/cbic.202300831
Goles M, Daza A, Cabas-Mora G, Sarmiento-Varón L, Sepúlveda-Yañez J, Anvari-Kazemabad H, Davari MD, Uribe-Paredes R, Olivera-Nappa Á, Navarrete MA, Medina-Ortiz D. Peptide-based drug discovery through artificial intelligence: towards an autonomous design of therapeutic peptides, Briefings in Bioinformatics, Volume 25, Issue 4, July 2024, bbae275, Doi: https://doi.org/10.1093/bib/bbae275
Lee AC, Harris JL, Khanna KK, Hong JH. A Comprehensive Review on Current Advances in Peptide Drug Development and Design. Int J Mol Sci. 2019;20(10):2383. Published 2019 May 14. doi: https://doi.org/10.3390/ijms20102383
Thallaj NK, Przybilla J, Welter R, Mandon D. A ferrous center as a reaction site for hydration of a nitrile group into a carboxamide in mild conditions. J. Am. Chem. Soc. 2008, 130, 2414-2415. Doi: https://doi.org/10.1021/ja710560g
Thallaj N. Microwave-Assisted Synthesis of Oxadiazole and Thiazolidine Derivatives. Indian Journal of Advanced Chemistry, 1, 3, 2022. 10-14. DOI: https://doi.org/10.54105/ijac.d2015.102222
Thallaj N. Quick Review of Chemistry Related to the [Fe]- Hydrogenases. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) 2022. 2,4, 1-15. DOI: https://doi.org/10.54105/ijapsr.C4016.062422
Thallaj N. A Short Review of Some Examples of the Binding of Fullerenes C60 to Transition Metal Complexes. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) 2022. 2,6, 1-12. DOI: https://doi.org/10.54105/ijapsr.C4015.102622
Thallaj N. Review of a Few Selected Examples of Intermolecular Dioxygenases Involving Molecular Oxygen and Non-Heme Iron Proteins. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) 2023. 3, 2, 1-18. DOI: https://doi.org/10.54105/ijapsr.C4011.023223
Thallaj N. A Brief Overview of the General Characteristics and Reactivity Towards Dioxygen of the Ferrous Tris (2-Pyridylmethyl Amine) Series Complexes is Presented. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) 2023. 3, 3, 1-18. DOI: https://doi.org/10.54105/ijapsr.C4012.043323
Song Y, Li J, Zhao F, Jin P. Drug shortages in China: a cross-sectional study. BMC Health Serv Res. 2023;23(1):438. Published 2023 May 4. doi: https://doi.org/10.1186/s12913-023-09295-w
Ravela R, Lyles A, Airaksinen M. National, and transnational drug shortages: a quantitative descriptive study of public registers in Europe and the USA. BMC Health Serv Res. 2022;22(1):940. Published 2022 Jul 22. doi: https://doi.org/10.1186/s12913-022-08309-3
Thallaj N. Detecting Antioxidant Behavior for Phenolic Content of Some Beauty Care Creams in Syrian Market. Indian Journal of Advanced Chemistry, vol. 2, no. 1, pp. 10–14, Jan. 2024. Doi: https://doi.org/10.54105/ijac.C2013.041322
Thallaj NK, Mandon D, White KA. The Design of Metal Chelates with a Biologically Related Redox‐Active Part: Conjugation of Riboflavin to Bis (2‐pyridylmethyl) amine Ligand and Preparation of a Ferric Complex Eur. J. of Inorg. Chem., 2007, 44–47. Doi: https://doi.org/10.1002/ejic.200600789
Thallaj NK, Orain PY, Thibon A, Sandroni M, Welter R, Mandon D. Steric Congestion at, and Proximity to, a Ferrous Center Leads to Hydration of α-Nitrile Substituents Forming Coordinated Carboxamides. Inorg Chem. 2014 Aug 4;53(15):7824-36. P7826-7827-7828. Doi: https://doi.org/10.1021/ic500096h
Wane A, Thallaj NK, Mandon D. The Reactivity of Molecular Dioxygen on a Series of Isostructural Dichloroferrous Complexes with Tripodal Tetraamine Ligands: General Access to µ-oxo Diferric Complexes, and Effect of α-Fluorination on the Kinetics of the Reaction. Chemistry A European Journal 14 (22), 6742-6753. Doi: https://doi.org/10.1002/chem.200701967
Besher S, Alallan L, Hasan Agha MI, Alshamaa I, Thallaj N. Influence of Soil Salinity on the Chemical Composition of Essential Oil of Rosmarinus officinalis in Syria. Research Journal of Pharmacy and Technology. 2024; 17(5):2282-8. doi: https://doi.org/10.52711/0974-360X.2024.00358
Khatib O, Alshimale T, Alsaadi A, Thallaj N. The Global Impact of HIV: A Comprehensive Review. IJAPSR, vol. 4, no. 3, pp. 6–19, Apr. 2024. Doi. https://doi.org/10.54105/ijapsr.C4040.04030424
Salloum R, Baddour F, Abbood A. A Questionnaire to Evaluate Undergraduate Students’ Consumption and Awareness of Non-Steroidal Anti-Inflammatory Drugs in Syria. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR), Volume-4 Issue-4, June 2024, pages 1-6. DOI: https://doi.org/10.54105/ijapsr.C4041.04040624
Zanboua R, Abbood A. Survey of Knowledge About the Interaction Between Food and Drugs Among the Syrian Population. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR), Volume-4 Issue-4, June 2024, pages 22-28. DOI: https://doi.org/10.54105/ijapsr.D4044.04040624
Mahfouz H, Assaf A, Abbood A. Survey of Usage and Awareness of Ibuprofen Among the Syrian Population. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR), Volume-4 Issue-5, August 2024, pages 23-28. DOI: https://doi.org/10.54105/ijapsr.E4048.04050824
Abbood A. Overview of Analytical Methods for Characterizing the Charge Heterogeneity of Antibody-Drug Conjugates. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR), Volume-4 Issue-5, August 2024, pages 16-22. DOI: https://doi.org/10.54105/ijapsr.E4047.04050824
Nouira R, Abbood A. Assessment of Knowledge About High Blood Pressure Among Syrians. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR), Volume-4 Issue-6, October 2024, pages 28-32. DOI: https://doi.org/10.54105/ijapsr.F4053.04061024
Al-Saroukhy R, Al-Kara R, Habib R, Abbood A. Assessment of use and Awareness of Diclofenac in Syria. International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR), Volume-4 Issue-6, October 2024, pages 1-6. DOI: https://doi.org/10.54105/ijapsr.F4052.04061024
Asaad RA. The association between Triglyceride-Glucose index and Hypertension status (stages and phenotypes) in Type II Diabetes Mellitus. Research Journal of Pharmacy and Technology. 2023:16(6): 2963-2968. DOI: https://doi.org/10.52711/0974-360X.2023.00489
Asaad RA. Evaluation of adiposity phenotypes: lipid accumulation product index, visceral adipose index, and body roundness index as predictor markers for metabolic syndrome development in type 2 diabetes mellitus. Bulletin of Pharmaceutical Sciences. Assiut. 2022; 45(2): 097-1107. DOI: https://doi.org/10.21608/bfsa.2022.271823
Asaad RA. Lymph Node Ratio (LNR) as a predictive factor in addition to pNstaging in Syrian-breast cancer patients at diagnosis. Research Journal of Pharmacy and Technology.2018;11(3):933-940. DOI: https://doi.org/10.5958/0974-360X.2018.00173.7
Asaad RA. Relative Fat Mass (RFM) Evaluates the Whole Body Fat (WBF) and predicts Cardio-metabolic Disorders as a new obesity marker in Syrian-population. Research Journal of Pharmacy and Technology. 2023; 16(9):4399-5. doi: https://doi.org/10.52711/0974-360X.2023.00719
Norboyeva Umida Toshtemirovna, Kholliyev Askar Ergashovich, Physiology, Productivity and Cotton Plant Adaptation under the Conditions of Soil Salinity. (2019). In International Journal of Recent Technology and Engineering (Vol. 8, Issue 2S3, pp. 1611–1613). Doi: https://doi.org/10.35940/ijrte.b1293.0782s319
Park, H. (2022). The Simplest Pharmacokinetic Equation in ADC (Antibody Drug Conjugate) or PDC (Peptide Drug Conjugate) Research. In International Journal of Advanced Pharmaceutical Sciences and Research (Vol. 2, Issue 5, pp. 1–4). Doi: https://doi.org/10.54105/ijapsr.c4017.082522